Article
Triaging of α-helical proteins to the mitochondrial outer membrane by distinct chaperone machinery based on substrate topology.
Molecular cell - 21 Mar 2024
Muthukumar Gayathri, Stevens Taylor A, Inglis Alison J, Esantsi Theodore K, Saunders Reuben A, Schulte Fabian, Voorhees Rebecca M, Guna Alina, Weissman Jonathan S
Abstract excerpt
Mitochondrial outer membrane ⍺-helical proteins play critical roles in mitochondrial-cytoplasmic communication, but the rules governing the targeting and insertion of these biophysically diverse proteins remain unknown. Here, we first defined the complement of required mammalian biogenesis machinery through genome-wide CRISPRi screens using topologically distinct membrane proteins. Systematic analysis of nine...
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