Article

Protein domain characterization reveals human MIC60 tolerates loss of helical bundle domain

2026-03-24

Abstract excerpt

<h4>SUMMARY</h4> The mitochondrial contact site and cristae organizing system (MICOS) is essential for cristae junction formation and inner mitochondrial membrane architecture. To define how MICOS integrity is established and maintained, we generated conditional deletion models of Immt (encoding MIC60), a core MICOS subunit, in tissue-specific settings and in cultured cells. Liver-specific deletion of Immt in m...

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Literature Corpus work: bc5c12fb-b7c7-5ad7-8542-170bfb947fb6
DOI: 10.64898/2026.03.19.713006

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