Article

Structural evolution of the MTCH family of mitochondrial insertases

2026-02-18

Abstract excerpt

We demonstrate that MTCH2 is the defining member of a large family of mitochondrial outer membrane (OM) insertases. MTCH insertases are conserved across holozoa and have diverged from the solute carrier 25 transporters. The cryoelectron microscopy structure of the 33 kDa human MTCH2 revealed that evolution of its insertase activity required loss of a transmembrane helix, which created a lipid-accessible hydrophili...

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Literature Corpus work: 14ef3799-5e7d-53c0-9122-2b58f26ed7b9
DOI: 10.64898/2026.02.17.705849

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