Article

Computational Identification of Migrating T cells in Spatial Transcriptomics Data

2024-10-27

Abstract excerpt

T cells are the central players in antitumor immunity, and effective tumor killing depends on their ability to infiltrate into the tumor microenvironment (TME) while maintaining normal cytotoxicity. However, late-stage tumors develop immunosuppressive mechanisms that impede T cell movement and induce exhaustion. Investigating T cell migration in human tumors in vivo could provide novel insights into tumor immune e...

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Literature Corpus work: 4cdfbeba-8f00-519d-afa3-50328986101d
DOI: 10.1101/2024.10.23.619870

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