Article

Immune and non-immune cell fencing of tumor cells is a widespread and functionally relevant spatial pattern in solid cancers

2025-08-13

Abstract excerpt

Solid tumors are characterized by a spatially heterogeneous mixture of cancer cells, immune cells and other non-tumor cells. Recent characterization of the heterogeneity at the single cell level has revealed spatial patterns of different cell types often lacking a simple geometric structure associated with cancer progression. Here we investigated the occurrence of physical fencing of tumor cells by specific immune...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: a4436177-a798-56bb-aca4-95ffec9ace1c
DOI: 10.1101/2025.08.11.669531

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Immune and non-immune cell fencing of tumor cells is a widespread and functionally relevant spatial pattern in solid cancersDOI 10.1101/2025.08.11.669531Read

Spatial organization and stochastic fluctuations of immune cells impact clinical responsiveness to immune checkpoint inhibitors in patients with melanomaSemantic proximity Read

Prognostic significance of spatial immune profiles in human solid cancersSemantic proximity Read

Temporal and spatial composition of the tumor microenvironment predicts response to immune checkpoint inhibitionSemantic proximity Read

Delineating spatial cell-cell interactions in the solid tumour microenvironment through the lens of highly multiplexed imagingSemantic proximity Read

Single-cell spatial atlas of tertiary lymphoid structures in ovarian cancerSemantic proximity Read

Tissue biomarkers of immune checkpoint inhibitor therapySemantic proximity Read

Tumor-Immune Partitioning and Clustering (TIPC) algorithm reveals distinct signatures of tumor-immune cell interactions within the tumor microenvironmentSemantic proximity Read

Single-cell spatial analysis of tumor immune architecture in diffuse large B cell lymphomaSemantic proximity Read

Integrated single-cell and spatial analysis identifies context-dependent myeloid-T cell interactions in head and neck cancer immune checkpoint blockade responseSemantic proximity Read

Single-cell spatial analysis of tumor immune architecture in diffuse large B-cell lymphomaSemantic proximity Read

The tumor microenvironment across four dimensions: assessing space and time in cancer biologySemantic proximity Read

Multiomics and spatial mapping characterizes human CD8 + T cell states in cancerSemantic proximity Read