Back to search

Article

Functional γδT-omics pipeline reveals compartmentalization of Vδ1⁺ T cell migration, tumor-reactivity, and clonality in human colorectal cancer

2025-08-23

Abstract excerpt

γδT cells play a pivotal role in cancer immune surveillance, yet the current knowledge of their function across the compartments in solid tumors is meager. To address this gap, we developed a comprehensive γδT-omics platform that integrates functional screening, biomimetic migration assays, γδTCR repertoire analysis, and transcriptomic profiling. Using matched samples from 31 patients with microsatellite-stable co...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
630c06a2-ff55-5beb-8d06-d6a6ba05f754
DOI
10.1101/2025.08.19.671055
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Functional γδT-omics pipeline reveals compartmentalization of Vδ1⁺ T cell migration, tumor-reactivity, and clonality in human colorectal cancerDOI 10.1101/2025.08.19.671055
Single cell dynamics of tumor specificity vs bystander activity in CD8+ T cells define the diverse immune landscapes in colorectal cancerSemantic proximity
Dissecting the mechanisms of intestinal immune homeostasis by analyzing T-cell immune response in Crohn's disease and colorectal cancerSemantic proximity
Integrated Single‐Cell RNA ‐Seq Reveals Immunosuppressive Mechanisms of Treg Cell Differentiation and Tumor Microenvironment Interactions in Colorectal CancerSemantic proximity
Precursor exhausted CD8+T cells in colorectal cancer tissues associated with patient’s survival and immunotherapy responsivenessSemantic proximity
Multiregion single‐cell sequencing reveals the transcriptional landscape of the immune microenvironment of colorectal cancerSemantic proximity
Multiplexed single-cell analysis reveals prognostic and nonprognostic T cell types in human colorectal cancerSemantic proximity
Revisiting the immune microenvironment of human colorectal cancer in the era of single-cell and spatial omicsSemantic proximity
Gut γδ T cells as guardians, disruptors, and instigators of cancerSemantic proximity
The functional and phenotypic diversity of single T-cell infiltrates in human colorectal cancer as correlated with clinical outcomeSemantic proximity
Tissue-embedded CD4⁺ plasticity defines mucosal immunity in Inflammatory Bowel DiseaseSemantic proximity
Integrated multi-omics unveils novel immune signature for predicting prognosis in colon cancer patientsSemantic proximity
Mapping of the T-cell Landscape of Biliary Tract Cancer Unravels Anatomic Subtype-Specific HeterogeneitySemantic proximity
Select a neighboring publication to make it the new centre.