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Tumor-agnostic transcriptome-based classifier identifies spatial infiltration patterns of CD8+ T cells in the tumor microenvironment and predicts clinical outcome in early- and late-phase clinical trials

2023-10-03

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Background</h4> The immune status of a patient’s tumor microenvironment (TME) may guide therapeutic interventions with cancer immunotherapy and help identify potential resistance mechanisms. Currently, patients’ immune status is mostly classified based on CD8+ tumor-infiltrating lymphocytes. An unmet need exists for comparable and reliable precision immunophenotyping tools that would facili...

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Literature Corpus work: 0a90697d-1e7c-5bfa-810e-757f8ee98d9d
DOI: 10.1101/2023.10.02.560086

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