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Tumor-associated macrophage clusters linked to immunotherapy in a pan-cancer census

9 Aug 2024

Abstract excerpt

Transcriptional heterogeneity of tumor-associated macrophages (TAMs) has been investigated in individual cancers, but the extent to which these states transcend tumor types and represent a general feature of cancer remains unclear. We performed pan-cancer single-cell RNA sequencing analysis across nine cancer types and identified distinct monocyte/TAM composition patterns. Using spatial analysis from clinical...

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PMID: 39117688
DOI: 10.1038/s41698-024-00660-4

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