Article

Single Cell Spatial Transcriptomics Reveals Immunotherapy-Driven Bone Marrow Niche Remodeling in AML

2025-01-27

Abstract excerpt

<h4>Summary</h4> Given the successful graft-versus-leukemia cell treatment effect observed with allogeneic hematopoietic stem cell transplant for patients with refractory or relapsed acute myeloid leukemia, immunotherapies have also been investigated in the nontransplant setting. Here, we use a multi-omic approach to investigate spatiotemporal interactions in the bone marrow niche between leukemia cells and immun...

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Literature Corpus work: 47fac231-c525-56c1-b812-91cb56b5aff1
DOI: 10.1101/2025.01.24.634753

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