Article

Signatures of digital Polycomb regulation in functional iPSC heterogeneity between individuals

2025-07-30

Abstract excerpt

Induced pluripotent stem cells (iPSCs) show substantial heterogeneity between individuals in their capacity to differentiate into various cell types, hindering their translational application. To explore the causes of this variability, we analysed a panel of ten human iPSC lines, evaluating their differentiation efficiency for two different fates, profiling their transcriptome and chromatin state. Using a machine...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 4cbf3503-0380-568b-811e-52476f9185c1
DOI: 10.1101/2025.07.25.666753

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Signatures of digital Polycomb regulation in functional iPSC heterogeneity between individualsDOI 10.1101/2025.07.25.666753Read

Analysis of Transcriptional Variability in a Large Human iPSC Library Reveals Genetic and Non-genetic Determinants of Heterogeneity.Semantic proximity Read

Transcription factors that convert adult cell identity are differentially polycomb repressed.Semantic proximity Read

Predictive control of human pancreatic cell fate using a digital model of <i>in vitro</i> differentiationSemantic proximity Read

Cell differentiation modifies the p53 transcriptional program through a combination of gene silencing and constitutive transactivationSemantic proximity Read

Single-cell epigenomic reconstruction of developmental trajectories in human neural organoid systems from pluripotencySemantic proximity Read

Cell-type and dynamic state govern genetic regulation of gene expression in heterogeneous differentiating culturesSemantic proximity Read

Network analysis of promoter interactions reveals the hierarchical differences in genome organisation between human pluripotent statesSemantic proximity Read

Histone H3K27 methylation states are sequentially catalyzed in cycling cellsSemantic proximity Read

Analysis of chromatin-state plasticity identifies cell-type-specific regulators of H3K27me3 patterns.Semantic proximity Read

Machine learning uncovers cell identity regulator by histone code.Semantic proximity Read

Polycomb Group Proteins: Multi-Faceted Regulators of Somatic Stem Cells and CancerSemantic proximity Read

Poising and connectivity of emergent human developmental enhancers in the transition from naive to primed pluripotencySemantic proximity Read