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Article

Analysis of chromatin-state plasticity identifies cell-type-specific regulators of H3K27me3 patterns.

Proceedings of the National Academy of Sciences of the United States of America - 21 Jan 2014

Pinello Luca, Xu Jian, Orkin Stuart H, Yuan Guo-Cheng

Abstract excerpt

Chromatin states are highly cell-type-specific, but the underlying mechanisms for the establishment and maintenance of their genome-wide patterns remain poorly understood. Here we present a computational approach for investigation of chromatin-state plasticity. We applied this approach to investigate an ENCODE ChIP-seq dataset profiling the genome-wide distributions of the H3K27me3 mark in 19 human cell lines. We...

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Identifiers

PMID: 24395799
DOI: 10.1073/pnas.1322570111
PMCID: PMC3903219

Genes

TAL1
GFI1B

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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