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Article

Analysis of Transcriptional Variability in a Large Human iPSC Library Reveals Genetic and Non-genetic Determinants of Heterogeneity.

Cell stem cell - 6 Apr 2017

Carcamo-Orive Ivan, Hoffman Gabriel E, Cundiff Paige, Beckmann Noam D, D'Souza Sunita L, Knowles Joshua W, Patel Achchhe, Papatsenko Dimitri, Abbasi Fahim, Reaven Gerald M, Whalen Sean, Lee Philip, Shahbazi Mohammad, Henrion Marc Y R, Zhu Kuixi, Wang Sven, Roussos Panos, Schadt Eric E, Pandey Gaurav, Chang Rui, Quertermous Thomas, Lemischka Ihor

Abstract excerpt

Variability in induced pluripotent stem cell (iPSC) lines remains a concern for disease modeling and regenerative medicine. We have used RNA-sequencing analysis and linear mixed models to examine the sources of gene expression variability in 317 human iPSC lines from 101 individuals. We found that ∼50% of genome-wide expression variability is explained by variation across individuals and identified a set of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 28017796
DOI: 10.1016/j.stem.2016.11.005
PMCID: PMC5384872

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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