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Cell differentiation modifies the p53 transcriptional program through a combination of gene silencing and constitutive transactivation

21 Jan 2023

Abstract excerpt

The p53 transcription factor is a master regulator of cellular responses to stress that is commonly inactivated in diverse cancer types. Despite decades of research, the mechanisms by which p53 impedes tumorigenesis across vastly different cellular contexts requires further investigation. The bulk of research has been completed using in vitro studies of cancer cell lines or in vivo studies in mouse models, but...

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PMID: 36681780
DOI: 10.1038/s41418-023-01113-4

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