Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Relative contributions of the ERG11VF125AL and MRR1AN647T mutations to fluconazole resistance in Clade III Candidozyma (Candida) auris clinical isolates.

Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases - 1 Feb 2026

Barker Katherine S, Zhang Qing, Peters Tracy L, Rybak Jeffrey M, Morschhäuser Joachim, Cuomo Christina A, Rogers P David

Abstract excerpt

OBJECTIVES: Candidozyma (Candida) auris is an emerging fungal pathogen of global concern that often exhibits multidrug resistance. Of the six described C. auris clades, Clade III has been found to be nearly universally fluconazole resistant, and almost every Clade III isolate described carries a mutation leading to a VF125AL substitution in ERG11, the gene encoding the fluconazole target lanosterol...

Read the complete abstract on PubMed

Topics

Fluconazole
Antifungal Agents
Drug Resistance, Fungal
Humans
Microbial Sensitivity Tests

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Fungal Proteins

Candida auris

Mutation

Triazoles

Sterol 14-Demethylase

Source

Open in PubMed Open full text

Identifiers

PMID: 41115594
DOI: 10.1016/j.cmi.2025.10.009
PMCID: PMC12713649

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 25 Oct 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Relative contributions of the ERG11VF125AL and MRR1AN647T mutations to fluconazole resistance in Clade III Candidozyma (Candida) auris clinical isolates.PMID 41115594Read ↗

Relative contributions of the <i>ERG11</i> <sup>VF125AL</sup> and <i>MRR1A</i> <sup>N647T</sup> mutations to fluconazole resistance in Clade III <i>Candidozyma</i> ( <i>Candida</i> ) <i>auris</i> clinical isolatesSemantic proximity Read ↗

Delineation of the Direct Contribution of Candida auris ERG11 Mutations to Clinical Triazole Resistance.Semantic proximity Read ↗

Mutations in <i>TAC1B</i> drive <i>CDR1</i> and <i>MDR1</i> expression and azole resistance in <i>C. auris</i>Semantic proximity Read ↗

Precise genome editing underlines the distinct contributions of mutations in ERG11, ERG3, MRR1, and TAC1 genes to antifungal resistance in Candida parapsilosis.Semantic proximity Read ↗

Mutations in ERG11, TAC1B, and CDR1 reduce fluconazole accumulation in drug-resistant Candidozyma auris isolates.Semantic proximity Read ↗

Trends in Antifungal Resistance and Mechanistic Insights Into Azole Resistance in Candida (Candidozyma) auris: A 13-Year Study of a Comprehensive Set of Clinical Isolates From India.Semantic proximity Read ↗

Mutations in TAC1B drive increased CDR1 and MDR1 expression and azole resistance in Candida auris.Semantic proximity Read ↗

Exploration of novel mechanisms of azole resistance in Candida auris.Semantic proximity Read ↗

Genomic diversity across <i>Candida auris</i> clinical isolates shapes rapid development of antifungal resistance <i>in vitro</i> and <i>in vivo</i>Semantic proximity Read ↗

Mutations in <i>TAC1B</i> : a novel genetic determinant of clinical fluconazole resistance in <i>C. auris</i>Semantic proximity Read ↗

Genomic Diversity across Candida auris Clinical Isolates Shapes Rapid Development of Antifungal Resistance In Vitro and In VivoSemantic proximity Read ↗

Mutations in transcription factors that confer fluconazole resistance also confer reduced susceptibility to manogepix in <i>Candida auris</i> , <i>Candida albicans</i> , <i>Candida parapsilosis</i> , and <i>Candida glabrata</i> ( <i>Nakaseomyces glabratus</i> )Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.