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Coordinated regulation of Mdr1- and Cdr1-mediated protection from antifungals by the Mrr1 transcription factor in emerging <i>Candida</i> spp

2025-05-06

Abstract excerpt

<h4>ABSTRACT</h4> Infections caused by the emerging pathogenic yeast Clavispora (Candida) lusitaniae can be difficult to manage due to multi-drug resistance. Resistance to the frontline antifungal fluconazole (FLZ) in Candida spp. is commonly acquired through gain-of-function (GOF) mutations in the gene encoding the transcription factor Mrr1. These activated Mrr1 variants enhance FLZ efflux via upregulation of...

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Literature Corpus work
4f8bc603-c9f3-50ea-8442-ae0a33b88fc3
DOI
10.1101/2025.05.04.652153
Open publication

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Coordinated regulation of Mdr1- and Cdr1-mediated protection from antifungals by the Mrr1 transcription factor in emerging <i>Candida</i> sppDOI 10.1101/2025.05.04.652153
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