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Relative contributions of the <i>ERG11</i> <sup>VF125AL</sup> and <i>MRR1A</i> <sup>N647T</sup> mutations to fluconazole resistance in Clade III <i>Candidozyma</i> ( <i>Candida</i> ) <i>auris</i> clinical isolates

2025-03-31

Abstract excerpt

<h4>Objectives</h4> Candidozyma ( Candida ) auris is an emerging fungal pathogen of global concern that often exhibits multi-drug resistance. Over 90% of isolates are resistant to fluconazole. Of the six described clades of C. auris , Clade III has been found to be nearly universally fluconazole resistant and almost every Clade III isolate described carries a mutation in the gene encoding the fluconazole targe...

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Literature Corpus work
24c1d2d6-2e7f-533d-97b1-500e334e720c
DOI
10.1101/2025.03.31.646430
Open publication

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Relative contributions of the <i>ERG11</i> <sup>VF125AL</sup> and <i>MRR1A</i> <sup>N647T</sup> mutations to fluconazole resistance in Clade III <i>Candidozyma</i> ( <i>Candida</i> ) <i>auris</i> clinical isolatesDOI 10.1101/2025.03.31.646430
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