Article

Mechano-osmotic signals control chromatin state and fate transitions in pluripotent stem cells

2024-09-07

Abstract excerpt

Acquisition of specific cell shapes and morphologies is a central component of cell fate transitions. Although signaling circuits and gene regulatory networks that regulate pluripotent stem cell differentiation have been intensely studied, how these networks are integrated in space and time with morphological transitions and mechanical deformations to control state transitions remains a fundamental open question....

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Identifiers and source

Literature Corpus work: 4ca4c55f-a728-5347-b88e-3355ae07079c
DOI: 10.1101/2024.09.07.611779

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