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Article

Structure-function analysis of SH3 domains: SH3 binding specificity altered by single amino acid substitutions.

Molecular and cellular biology - 1 Oct 1995

Weng Z, Rickles R J, Feng S, Richard S, Shaw A S, Schreiber S L, Brugge J S

Abstract excerpt

SH3 domains mediate intracellular protein-protein interactions through the recognition of proline-rich sequence motifs on cellular proteins. Structural analysis of the Src SH3 domain (Src SH3) complexed with proline-rich peptide ligands revealed three binding sites involved in this interaction: two hydrophobic interactions (between aliphatic proline dipeptides in the SH3 ligand and highly conserved aromatic...

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Identifiers

PMID: 7565714
DOI: 10.1128/MCB.15.10.5627
PMCID: PMC230813

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