Article
Structure-function analysis of SH3 domains: SH3 binding specificity altered by single amino acid substitutions.
Molecular and cellular biology - 1 Oct 1995
Weng Z, Rickles R J, Feng S, Richard S, Shaw A S, Schreiber S L, Brugge J S
Abstract excerpt
SH3 domains mediate intracellular protein-protein interactions through the recognition of proline-rich sequence motifs on cellular proteins. Structural analysis of the Src SH3 domain (Src SH3) complexed with proline-rich peptide ligands revealed three binding sites involved in this interaction: t...
Topics
- 3T3 Cells
- Amino Acid Sequence
- Animals
- Arginine
- Aspartic Acid
- DEAD-box RNA Helicases
- Heterogeneous-Nuclear Ribonucleoproteins
- Mice
- Mice, Inbred BALB C
- Molecular Sequence Data
- Mutation
- Nuclear Proteins
- Peptides
- Phosphorylation
- Proline
- Protein Binding
- Protein Kinases
- Proto-Oncogene Proteins c-abl