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Article

Structural basis for PDZ domain interactions in the post-synaptic density scaffolding protein Shank3.

Journal of neurochemistry - 1 Jun 2018

Ponna Srinivas Kumar, Ruskamo Salla, Myllykoski Matti, Keller Corinna, Boeckers Tobias M, Kursula Petri

Abstract excerpt

The Shank proteins are crucial scaffolding elements of the post-synaptic density (PSD). One of the best-characterized domains in Shank is the PDZ domain, which binds to C-terminal segments of several other PSD proteins. We carried out a detailed structural analysis of Shank3 PDZ domain-peptide complexes, to understand determinants of binding affinity towards different ligand proteins. Ligand peptides from four...

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Identifiers

PMID: 29473168
DOI: 10.1111/jnc.14322

Genes

PSD

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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