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Article

Structural characterization of 14-3-3ζ in complex with the human Son of sevenless homolog 1 (SOS1).

Journal of structural biology - 1 Jun 2018

Ballone Alice, Centorrino Federica, Wolter Madita, Ottmann Christian

Abstract excerpt

The deviant Ras activation machinery is found in approximately 30% of all human cancers. SOS1 is an important protagonist of this pathway that plays a key-role in aberrant cell proliferation and differentiation. Interaction of SOS1 with 14-3-3 proteins modulates SOS1 activity in Ras-MAPK signaling. In the present study, we analyze the 14-3-3/SOS1 protein-protein interaction (PPI) by different biochemical assays...

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Source

Identifiers

PMID: 29408703
DOI: 10.1016/j.jsb.2018.01.011

Genes

SOS1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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