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Article

Diversity in the SH2 domain family phosphotyrosyl peptide binding site.

Protein engineering - 1 Mar 2003

Campbell S J, Jackson R M

Abstract excerpt

Src homology 2 (SH2) domains are approximately 100 residue phosphotyrosyl peptide binding modules found in signalling proteins and are important targets for therapeutic intervention. The peptide binding site is evolutionarily well conserved, particularly at the two major binding pockets, pTyr and...

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Source

Identifiers

PMID: 12702802
DOI: 10.1093/proeng/gzg025

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-12702802-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

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