Diversity in the SH2 domain family phosphotyrosyl peptide binding site.

Abstract excerpt

Src homology 2 (SH2) domains are approximately 100 residue phosphotyrosyl peptide binding modules found in signalling proteins and are important targets for therapeutic intervention. The peptide binding site is evolutionarily well conserved, particularly at the two major binding pockets, pTyr and pTyr + 3. We present a computational analysis of diversity within the peptide binding region and discuss molecular...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Binding Sites
• Share to Evolution, Molecular
• Share to Ligands