Article

Functional selection in SH3-mediated activation of the PI3 kinase

2024-04-30

Abstract excerpt

<h4>ABSTRACT</h4> The phosphoinositide-3 kinase (PI3K), a heterodimeric enzyme, plays a pivotal role in cellular metabolism and survival. Its deregulation is associated with major human diseases, particularly cancer. The p85 regulatory subunit of PI3K binds to the catalytic p110 subunit via its C-terminal domains, stabilising it in an inhibited state. Certain Src homology 3 (SH3) domains can activate p110 by bind...

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Literature Corpus work: 3a2f75c0-833f-588d-ba60-34ab776e1608
DOI: 10.1101/2024.04.30.591319

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