Article

Small-molecule inhibition of Lats kinases rescues slit diaphragm functionality

2026-06-11

Abstract excerpt

<title>Abstract</title> <p> The Hippo signaling pathway plays a crucial role in regulating cell proliferation, differentiation, and apoptosis, thereby preventing excessive organ growth. It exerts this control via the kinases LATS1/2, which regulate the activity of the co-transcription factors YAP and TAZ. In the glomeruli of the kidney, podocytes are the indispensable cellular building block of the blood-urine f...

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Literature Corpus work: 4c694f4f-5ae2-5275-a948-23d6bae83d5c
DOI: 10.21203/rs.3.rs-9896768/v1

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