Article

Selective endocytosis controls slit diaphragm maintenance and dynamics

2022-03-02

Abstract excerpt

<h4>SUMMARY</h4> The kidneys generate about 180 liters of primary urine per day by filtration of plasma. An essential part of the filtration barrier is the slit diaphragm, a multiprotein complex containing nephrin as major component. Filter dysfunction typically manifests with proteinuria and mutations in endocytosis regulating genes were discovered as causes of proteinuria. However, it is unclear how endocytosis...

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Literature Corpus work: b263d72e-caf2-5d0a-9092-38c755d006d0
DOI: 10.1101/2022.03.01.482547

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