Article

Preclinical Characterization of Hippo pathway inhibition: Insights from Pharmacological and Genetic Studies

2026-08-04

Abstract excerpt

The Hippo pathway is an evolutionarily conserved regulator of growth, regeneration, and organ homeostasis, and while its dysregulation is well established in cancer, the effects of inhibiting this pathway on normal tissues are less understood. Here we have systematically investigated the impact of Hippo pathway inhibition by comparing pharmacologic perturbation using a covalent small-molecule TEAD inhibitor (TEADi...

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Literature Corpus work: 953e7689-7c0d-5edc-ba23-e85a81abe721
DOI: 10.64898/2026.08.01.742182

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