Article

Small-molecule inhibition of Lats kinases promotes Yap-dependent proliferation in postmitotic mammalian tissues

2020-02-12

Abstract excerpt

<h4>Summary</h4> Hippo signaling is an evolutionarily conserved pathway that restricts organ growth during development and suppresses regeneration in mature organs 1–3 . Using a high-throughput phenotypic screen, we have identified a potent, non-toxic, and reversible inhibitor of Hippo signaling. An ATP-competitive inhibitor of Lats kinases, the compound causes Yap-dependent proliferation of murine supporting ce...

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Literature Corpus work: 41254212-0a02-52bc-86ea-08454a5c6f75
DOI: 10.1101/2020.02.11.944157

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