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Article

Kindlin-2 in Sertoli cells is essential for testis development and male fertility in mice

11 Jun 2021

Abstract excerpt

Kindlin-2 is known to play important roles in the development of mesoderm-derived tissues including myocardium, smooth muscle, cartilage and blood vessels. However, nothing is known for the role of Kindlin-2 in mesoderm-derived reproductive organs. Here, we report that loss of Kindlin-2 in Sertoli cells caused severe testis hypoplasia, abnormal germ cell development and complete infertility in male mice....

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PMID: 34117213
DOI: 10.1038/s41419-021-03885-4

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