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The Hippo pathway regulator KIBRA promotes podocyte injury by inhibiting YAP signaling and disrupting actin cytoskeletal dynamics

6 Oct 2017

Abstract excerpt

Kidney podocytes represent a key constituent of the glomerular filtration barrier. Identifying the molecular mechanisms of podocyte injury and survival is important for better understanding and management of kidney diseases. KIBRA (kidney brain protein), an upstream regulator of the Hippo signaling pathway encoded by the Wwc1 gene, shares the pro-injury properties of its putative binding partner dendrin and...

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Share to Hippo pathway signaling and YAP/TAZ
Share to Renal Diseases and Glomerulopathies
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PMID: 28982981
DOI: 10.1074/jbc.m117.819029

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