Article

Development of an improved inhibitor of Lats kinases to promote regeneration of mammalian organs

2022-04-08

Abstract excerpt

The Hippo signaling pathway acts as a brake on regeneration in many tissues. This cascade of kinases culminates in the phosphorylation of the transcriptional cofactors Yap and Taz, whose concentration in the nucleus consequently remains low. Various types of cellular stress can reduce phosphorylation, however, resulting in the accumulation of Yap and Taz in the nucleus and subsequently in mitosis. We earlier ident...

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Literature Corpus work: 40330fe2-b8a1-5539-9379-40a834079f2d
DOI: 10.1101/2022.04.07.487521

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