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Article

YAP-mediated mechanotransduction determines the podocyte’s response to damage

11 Apr 2017

Abstract excerpt

was highly expressed in renal biopsies from glomerular disease patients. Although overexpression of human YAP in mice induced mild proteinuria, pharmacological inhibition of the interaction between YAP and its partner TEAD in rats ameliorated glomerular disease and reduced damage-induced mechanosignaling in the glomeruli. Thus, perturbation of YAP-dependent mechanosignaling is a potential therapeutic target for...

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Share to Erythrocyte Function and Pathophysiology
Share to Hippo pathway signaling and YAP/TAZ
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PMID: 28400537
DOI: 10.1126/scisignal.aaf8165

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