Article

JAK-STAT pathway activation compromises nephrocyte function in a <i>Drosophila</i> high-fat diet model of chronic kidney disease

2024-03-08

Abstract excerpt

<h4>ABSTRACT</h4> Chronic kidney disease is a major health issue and is gaining prevalence. Using a Drosophila model for chronic kidney disease, we show that a high-fat diet (HFD) disrupts the slit diaphragm filtration structure in nephrocytes, the fly functional equivalent of mammalian podocytes. The structural disruption resulted in reduced filtration function in the affected nephrocytes. We demonstrate that H...

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Literature Corpus work: aa6545aa-6146-5d68-a122-edfbbaf55032
DOI: 10.1101/2024.03.07.583967

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