Article

Serum Lipidome as an Early Peripheral Indicator in Familial Alzheimer’s Disease

2025-11-28

Abstract excerpt

Protein biomarkers in biofluids are highly sensitive indicators of prodromal cognitive impairment yet remain limited for primary prevention. Lipids, essential to brain structure and function, offer untapped prognostic value. Here, we identify a lipidomic signature in serum from asymptomatic PSEN1-E280A mutation carriers aged 6–40 years, that differentiate carriers from non-carriers with an AUC 80–90%. Similarly, t...

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Identifiers and source

Literature Corpus work: c8e16331-8d98-5397-9c76-6f2a27a0f69d
DOI: 10.1101/2025.11.25.690392

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