Article

The non-classic psychedelic muscimol suppresses inflammatory signaling and promotes neuroplasticity in schizophrenia-derived human cortical spheroids and astroglia

2026-04-12

Abstract excerpt

<h4>ABSTRACT</h4> Schizophrenia (SCZ) is increasingly linked to neuroimmune dysregulation and impaired synaptic plasticity, yet the cellular mechanisms connecting inflammatory signaling to neural dysfunction remain poorly understood. Using human induced pluripotent stem cell (iPSC)-derived cortical spheroids (hCS) and astrocytes from patients with SCZ and matched controls, we investigated the effects of GABA A r...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 4bc2df97-cfa3-5c9d-824b-1c7b8969f8bc
DOI: 10.64898/2026.04.08.717305

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

The non-classic psychedelic muscimol suppresses inflammatory signaling and promotes neuroplasticity in schizophrenia-derived human cortical spheroids and astrogliaDOI 10.64898/2026.04.08.717305Read

hiPSC-derived astrocytes from individuals with schizophrenia induce a dystrophic phenotype in microglial-like cellsSemantic proximity Read

hiPSC-Derived Astrocytes From Individuals With Schizophrenia Induce a Dystrophic Phenotype in Microglial-Like Cells.Semantic proximity Read

Patient iPSC-astrocytes show transcriptional and functional dysregulation in schizophreniaSemantic proximity Read

Induced pluripotent stem cell-derived astrocytes from patients with schizophrenia exhibit an inflammatory phenotype that affects vascularizationSemantic proximity Read

Regulation of synaptic connectivity in schizophrenia by mutual neuron-microglia interactionSemantic proximity Read

Induced pluripotent stem cell-derived astrocytes from patients with schizophrenia exhibit an inflammatory phenotype that affects vascularization.Semantic proximity Read

Assessing the relationships between neurological and psychiatric diseases with astrocyte subtypes and psychotropic medicationsSemantic proximity Read

Contribution of astrocytes to familial risk and clinical manifestation of schizophrenia.Semantic proximity Read

SARS-CoV-2 promotes microglial synapse elimination in human brain organoidsSemantic proximity Read

Gene-Expression Profiling Suggests Impaired Signaling via the Interferon Pathway in Cstb-/- Microglia.Semantic proximity Read

SARS-CoV-2 promotes microglial synapse elimination in human brain organoidsSemantic proximity Read

Identification of neuron-glia signaling feedback in human schizophrenia using patient-derived, mix-and-match forebrain assembloidsSemantic proximity Read