Article

SARS-CoV-2 promotes microglial synapse elimination in human brain organoids

2021-07-08

Abstract excerpt

<h4>ABSTRACT</h4> Neuropsychiatric manifestations are common in both the acute and post-acute phase of SARS-CoV-2 infection, but the mechanisms of these effects are unknown. In a newly established brain organoid model with innately developing microglia, we demonstrate that SARS-CoV-2 infection causes an extensive cell death and loss of post-synaptic termini. Despite limited neurotropism and a decelerating viral r...

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Literature Corpus work: 3e379ebb-1577-5992-b3ab-1db17a2d8945
DOI: 10.1101/2021.07.07.451463

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