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SARS-CoV-2 promotes microglial synapse elimination in human brain organoids

1 Oct 2022

Abstract excerpt

Neuropsychiatric manifestations are common in both the acute and post-acute phase of SARS-CoV-2 infection, but the mechanisms of these effects are unknown. In a newly established brain organoid model with innately developing microglia, we demonstrate that SARS-CoV-2 infection initiate neuronal cell death and cause a loss of post-synaptic termini. Despite limited neurotropism and a decelerating viral replication,...

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PMID: 36198765
DOI: 10.1038/s41380-022-01786-2

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