Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Synthesis and Evaluation of a Class of Compounds Inhibiting the Growth of Stromal Antigen 2 (STAG2)-Mutant Ewing Sarcoma Cells.

ChemMedChem - 4 May 2022

Zhang Nenggang, Lin Keng-Fu, Yang Christian, Peruski Scott, Pati Debananda, Gilbertson Scott R

Abstract excerpt

STAG2 (SA2) is a critical component of the cohesin complex that regulates gene expression and the separation of sister chromatids in cells. Mutations in STAG2 have been identified in over thirty different types of cancers including myeloid leukaemia, non-small cell lung, bladder and Ewing sarcoma. Selectively inhibiting cancer cells lacking of STAG2 is an attractive approach for the cancer therapy. Here we report...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Cycle Proteins
Share to Cell Line, Tumor

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mutation

Share to Sarcoma, Ewing

Source

Identifiers

PMID: 35018729
DOI: 10.1002/cmdc.202100653

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Synthesis and Evaluation of a Class of Compounds Inhibiting the Growth of Stromal Antigen 2 (STAG2)-Mutant Ewing Sarcoma Cells.PMID 35018729Read ↗

Inducing synthetic lethality for selective targeting of acute myeloid leukemia cells harboring <i>STAG2</i> mutationsSemantic proximity Read ↗

Mutational inactivation of STAG2 causes aneuploidy in human cancer.Semantic proximity Read ↗

Hardwired synthetic lethality within the cohesin complex in human cancer cellsSemantic proximity Read ↗

Synthetic lethality between the cohesin subunits <i>STAG1</i> and <i>STAG2</i> in diverse cancer contextsSemantic proximity Read ↗

Cohesin mutations in myeloid malignancies made simple.Semantic proximity Read ↗

STAG2 expression is associated with adverse survival outcomes and regulates cell phenotype in muscle-invasive bladder cancer.Semantic proximity Read ↗

Inducing synthetic lethality for selective targeting of acute myeloid leukemia cells harboring STAG2 mutations.Semantic proximity Read ↗

STAG2 mutations reshape the cohesin-structured spatial chromatin architecture to drive gene regulation in acute myeloid leukemia.Semantic proximity Read ↗

Glioblastoma cells containing mutations in the cohesin component STAG2 are sensitive to PARP inhibition.Semantic proximity Read ↗

<i>Drosophila SA1</i> expression prevents brain tumorigenesis and PARP-mediated cell eliminationSemantic proximity Read ↗

STAG2 Regulates Homologous Recombination Repair and Sensitivity to ATM InhibitionSemantic proximity Read ↗

Inhibition of a Selective SWI/SNF Function Synergizes with ATR Inhibitors in Cancer Cell KillingSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.