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Untangling the loops of STAG2 mutations in myelodysplastic syndrome.

Leukemia & lymphoma - 1 Jan 2025

Sudunagunta Varun S, Viny Aaron D

Abstract excerpt

Myelodysplastic syndrome (MDS) is a heterogeneous myeloid neoplasm that is hallmarked by the acquisition of genetic events that disrupt normal trilineage hematopoiesis and results in bone marrow dysfunction. Somatic genes involving transcriptional regulation, signal transduction, DNA methylation, and chromatin modification are often implicated in disease pathogenesis. The cohesin complex, composed of SMC1, SMC3,...

Topics

Humans
Myelodysplastic Syndromes
Mutation
Cell Cycle Proteins
Cohesins
Antigens, Nuclear
Chromosomal Proteins, Non-Histone
Prognosis
Genetic Predisposition to Disease

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 39264305
DOI: 10.1080/10428194.2024.2400210
PMCID: PMC11695156

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