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Article

Cohesin loss alters adult hematopoietic stem cell homeostasis, leading to myeloproliferative neoplasms

5 Oct 2015

Abstract excerpt

The cohesin complex (consisting of Rad21, Smc1a, Smc3, and Stag2 proteins) is critically important for proper sister chromatid separation during mitosis. Mutations in the cohesin complex were recently identified in a variety of human malignancies including acute myeloid leukemia (AML). To address the potential tumor-suppressive function of cohesin in vivo, we generated a series of shRNA mouse models in which...

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Identifiers

PMID: 26438359
DOI: 10.1084/jem.20151323

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