Alterations of cohesin complex genes in acute myeloid leukemia: differential co-mutations, clinical presentation and impact on outcome.

doi:10.1038/s41408-023-00790-1

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Article

Alterations of cohesin complex genes in acute myeloid leukemia: differential co-mutations, clinical presentation and impact on outcome.

Blood cancer journal - 24 Jan 2023

Eckardt Jan-Niklas, Stasik Sebastian, Röllig Christoph, Sauer Tim, Scholl Sebastian, Hochhaus Andreas, Crysandt Martina, Brümmendorf Tim H, Naumann Ralph, Steffen Björn, Kunzmann Volker, Einsele Hermann, Schaich Markus, Burchert Andreas, Neubauer Andreas, Schäfer-Eckart Kerstin, Schliemann Christoph, Krause Stefan W, Herbst Regina, Hänel Mathias, Hanoun Maher, Kaiser Ulrich, Kaufmann Martin, Rácil Zdenek, Mayer Jiri, Cerqueira Tiago, Kroschinsky Frank, Berdel Wolfgang E, Serve Hubert, Müller-Tidow Carsten, Platzbecker Uwe, Baldus Claudia D, Schetelig Johannes, Siepmann Timo, Bornhäuser Martin, Middeke Jan Moritz, Thiede Christian

Abstract excerpt

Functional perturbations of the cohesin complex with subsequent changes in chromatin structure and replication are reported in a multitude of cancers including acute myeloid leukemia (AML). Mutations of its STAG2 subunit may predict unfavorable risk as recognized by the 2022 European Leukemia Net recommendations, but the underlying evidence is limited by small sample sizes and conflicting observations regarding...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 36693840
DOI: 10.1038/s41408-023-00790-1
PMCID: PMC9873811

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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