Article

Development of potency, breadth and resilience to viral escape mutations in SARS-CoV-2 neutralizing antibodies

2021-03-08

Abstract excerpt

<h4>Summary</h4> Antibodies elicited in response to infection undergo somatic mutation in germinal centers that can result in higher affinity for the cognate antigen. To determine the effects of somatic mutation on the properties of SARS-CoV-2 spike receptor-binding domain (RBD)-specific antibodies, we analyzed six independent antibody lineages. As well as increased neutralization potency, antibody evolution chan...

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Literature Corpus work: 4b8f2808-682e-56fb-88eb-aae87ad92931
DOI: 10.1101/2021.03.07.434227

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