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Article

Fortuitous somatic mutations during antibody evolution endow broad neutralization against SARS-CoV-2 Omicron variants.

Cell reports - 30 May 2023

Wu Jianbo, Chen Zhenguo, Gao Yidan, Wang Zegen, Wang Jiarong, Chiang Bing-Yu, Zhou Yunjiao, Han Yuru, Zhan Wuqiang, Xie Minxiang, Jiang Weiyu, Zhang Xiang, Hao Aihua, Xia Anqi, He Jiaying, Xue Song, Mayer Christian T, Wu Fan, Wang Bin, Zhang Lunan, Sun Lei, Wang Qiao

Abstract excerpt

Striking antibody evasion by emerging circulating severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants drives the identification of broadly neutralizing antibodies (bNAbs). However, how a bNAb acquires increased neutralization breadth during antibody evolution is still elusive. Here, we identify a clonally related antibody family from a convalescent individual. One of the members, XG005, exhibits...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 37178120
DOI: 10.1016/j.celrep.2023.112503
PMCID: PMC10154539

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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