Article

Epitope-Driven Polyfunctional Divergence of SARS-CoV-2 RBD Antibodies

2025-08-26

Abstract excerpt

<h4>SUMMARY</h4> SARS-CoV-2 antibodies targeting the receptor binding domain (RBD) of the spike protein can potently neutralize infection and exert additional antiviral functions. Here, we characterize the functional profiles of human RBD-specific memory B-cell antibodies elicited by ancestral SARS-CoV-2 infection. While SARS-CoV2 neutralizing antibodies, mainly class 1 and 3 anti-RBD antibodies, often lose bindi...

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Literature Corpus work: 217224f3-3160-5977-a727-243be8556470
DOI: 10.1101/2025.08.26.672080

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