Article

A population antibody response against SARS-CoV-2 with differential neutralization activities towards the Delta and Omicron variants

2022-03-14

Abstract excerpt

<title>Abstract</title> <p>Population antibody response is believed to be important in selection of new variant viruses. We identified that SARS-CoV-2 infections elicit a population immune response mediated by a lineage of VH1-69 germline antibodies. The representative antibody R1-32 targets a novel semi-cryptic epitope defining a new class of RBD targeting antibodies. Binding to this non-ACE2 competing epitope l...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 46fbc349-a304-5c4f-8466-2891e9cd7826
DOI: 10.21203/rs.3.rs-1381122/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

A population antibody response against SARS-CoV-2 with differential neutralization activities towards the Delta and Omicron variantsDOI 10.21203/rs.3.rs-1381122/v1Read

SARS-CoV-2 Delta and Omicron variants evade population antibody response by mutations in a single spike epitope.Semantic proximity Read

Antibodies utilizing VL6-57 light chains target a convergent cryptic epitope on SARS-CoV-2 spike protein driving the genesis of Omicron variantsSemantic proximity Read

Antibodies utilizing VL6-57 light chains target a convergent cryptic epitope on SARS-CoV-2 spike protein and potentially drive the genesis of Omicron variantsSemantic proximity Read

SARS-CoV-2 breakthrough infections induce somatically hypermutated broadly neutralizing antibodies against heterologous variantsSemantic proximity Read

Shared IGHV1-69-encoded neutralizing antibodies contribute to the emergence of L452R substitution in SARS-CoV-2 variantsSemantic proximity Read

Structural basis of a public antibody response to SARS-CoV-2Semantic proximity Read

Molecular Basis of SARS-CoV-2 Omicron Variant Evasion from Shared Neutralizing Antibody ResponseSemantic proximity Read

Characterization of neutralizing antibodies from a SARS-CoV-2 infected individualSemantic proximity Read

Defining variant-resistant epitopes targeted by SARS-CoV-2 antibodies: A global consortium studySemantic proximity Read

Immune Evasion of SARS-CoV-2 Emerging Variants: What Have We Learnt So Far?Semantic proximity Read

Molecular basis of SARS-CoV-2 Omicron variant evasion from shared neutralizing antibody responseSemantic proximity Read

Cross neutralization of emerging SARS-CoV-2 variants of concern by antibodies targeting distinct epitopes on spikeSemantic proximity Read