Affinity maturation of SARS-CoV-2 neutralizing antibodies confers potency, breadth, and resilience to viral escape mutations.

doi:10.1016/j.immuni.2021.07.008

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Article

Affinity maturation of SARS-CoV-2 neutralizing antibodies confers potency, breadth, and resilience to viral escape mutations.

Immunity - 10 Aug 2021

Muecksch Frauke, Weisblum Yiska, Barnes Christopher O, Schmidt Fabian, Schaefer-Babajew Dennis, Wang Zijun, C Lorenzi Julio C, Flyak Andrew I, DeLaitsch Andrew T, Huey-Tubman Kathryn E, Hou Shurong, Schiffer Celia A, Gaebler Christian, Da Silva Justin, Poston Daniel, Finkin Shlomo, Cho Alice, Cipolla Melissa, Oliveira Thiago Y, Millard Katrina G, Ramos Victor, Gazumyan Anna, Rutkowska Magdalena, Caskey Marina, Nussenzweig Michel C, Bjorkman Pamela J, Hatziioannou Theodora, Bieniasz Paul D

Abstract excerpt

Antibodies elicited by infection accumulate somatic mutations in germinal centers that can increase affinity for cognate antigens. We analyzed 6 independent groups of clonally related severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) Spike receptor-binding domain (RBD)-specific antibodies from 5 individuals shortly after infection and later in convalescence to determine the impact of maturation over...

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Identifiers

PMID: 34331873
DOI: 10.1016/j.immuni.2021.07.008
PMCID: PMC8323339

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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