Article
SARS-CoV-2 Delta and Omicron variants evade population antibody response by mutations in a single spike epitope.
Nature microbiology - 1 Oct 2022
He Ping, Liu Banghui, Gao Xijie, Yan Qihong, Pei Rongjuan, Sun Jing, Chen Qiuluan, Hou Ruitian, Li Zimu, Zhang Yanjun, Zhao Jincun, Sun Hao, Feng Bo, Wang Qian, Yi Haisu, Hu Peiyu, Li Pingchao, Zhang Yudi, Chen Zhilong, Niu Xuefeng, Zhong Xiaolin, Jin Liang, Liu Xiaofeng, Qu Kun, Ciazynska Katarzyna A, Carter Andrew P, Briggs John A G, Chen Jizheng, Liu Jinsong, Chen Xinwen, He Jun, Chen Ling, Xiong Xiaoli
Abstract excerpt
Population antibody response is thought to be important in selection of virus variants. We report that SARS-CoV-2 infection elicits a population immune response that is mediated by a lineage of VH1-69 germline antibodies. A representative antibody R1-32 from this lineage was isolated. By cryo-EM, we show that it targets a semi-cryptic epitope in the spike receptor-binding domain. Binding to this non-ACE2...
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