Article

Broadly neutralizing antibodies targeting a conserved silent face of spike RBD resist extreme SARS-CoV-2 antigenic drift

2023-04-27

Abstract excerpt

<h4>Summary</h4> Developing broad coronavirus vaccines requires identifying and understanding the molecular basis of broadly neutralizing antibody (bnAb) spike sites. In our previous work, we identified sarbecovirus spike RBD group 1 and 2 bnAbs. We have now shown that many of these bnAbs can still neutralize highly mutated SARS-CoV-2 variants, including the XBB.1.5. Structural studies revealed that group 1 bnAbs...

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Literature Corpus work: 75a2e773-6133-5b90-8f0b-be73c25ecfde
DOI: 10.1101/2023.04.26.538488

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