Article

Fortuitous Somatic Mutations during Antibody Evolution Endow Broad Neutralization against SARS-CoV-2 Omicron Variants

2022-12-13

Abstract excerpt

<h4>ABSTRACT</h4> Striking antibody evasion by emerging circulating SARS-CoV-2 variants drives the identification of broadly neutralizing antibodies (bNAbs). However, how a bNAb acquires increased neutralization breadth during antibody evolution is still elusive. Here, we identified a clonally-related antibody family from a convalescent individual. One of the members, XG005, exhibited potent and broad neutralizin...

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Literature Corpus work: a5fc0a12-91cf-5065-ad7b-e3a09757419a
DOI: 10.1101/2022.12.12.520172

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