Article

Colorectal cancer progression to metastasis is associated with dynamic genome-wide biphasic 5-hydroxymethylcytosine accumulation

2025-02-27

Abstract excerpt

<h4>Background</h4> Colorectal cancer (CRC) progression from adenoma to adenocarcinoma is associated with global reduction in 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC). DNA hypomethylation continues upon liver metastasis. Here we examine 5hmC changes upon progression to liver metastasis. <h4>Results</h4> 5hmC is increased in metastatic liver tissue relative to the primary colon tumour and express...

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Literature Corpus work: 4b790474-4317-5da1-bccc-2a98e1d475a4
DOI: 10.1101/2025.02.21.639484

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