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Novel TCF21 high pericyte subpopulation promotes colorectal cancer metastasis by remodelling perivascular matrix

7 Sept 2022

Abstract excerpt

Objective Haematogenous dissemination is a prevalent route of colorectal cancer (CRC) metastasis. However, as the gatekeeper of vessels, the role of tumour pericytes (TPCs) in haematogenous metastasis remains largely unknown. Here, we aimed to investigate the heterogeneity of TPCs and their effects on CRC metastasis. Design TPCs were isolated from patients with CRC with or without liver metastases and analysed by...

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PMID: 36805487
DOI: 10.1136/gutjnl-2022-327913

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