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Article

Targeting m 6 A reader YTHDF1 augments antitumour immunity and boosts anti-PD-1 efficacy in colorectal cancer

30 Jan 2023

Abstract excerpt

Objective The role of N 6 -methyladenosine (m 6 A) in tumour immune microenvironment (TIME) remains understudied. Here, we elucidate function and mechanism of YTH N 6 -methyladenosine RNA binding protein 1 (YTHDF1) in colorectal cancer (CRC) TIME. Design Clinical significance of YTHDF1 was assessed in tissue microarrays (N=408) and TCGA (N=526) cohorts. YTHDF1 function was determined in syngeneic tumours,...

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PMID: 36717220
DOI: 10.1136/gutjnl-2022-328845

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